thalassemia oral manifestations

The signs symptoms and potential complications of the thalassemias are discussed. Thalassemia is an autosomal recessive hemoglobinopathy that originated in the Mediterranean region.

Oral Manifestations Of Systemic Diseases

A case report of 25 yearsold β.

. The purpose of this study was to identify special oral and dentofacial manifestations of β-thalassemia major ΒTM in Emarati children in Dubai UAE. A total of 38 ΒTM and 76 healthy Emirati children were recruited. Thalessemia is a hereditary form of anemia with 5 clinical classifications.

Thalassemia is a single gene inherited blood diseases. In the future gene therapy may be expected to allow a normal facial appearance thanks to complete healing of the patient. Any dental surgical procedure for such patients should be done under antibiotic cover and immediately after transfusion.

Individuals with thalassemia have variable degrees of anemia and extramedullary hematopoiesis which in turn can cause bone changes impaired growth and iron overload. Fatigue Weakness Pale or yellowish skin Facial bone deformities Slow growth Abdominal swelling Dark urine Some babies show signs and symptoms of thalassemia at birth. Iron-deficiency anemia and folic acid deficiency may produce symptoms of glossodynia and loss of papillae on the tongue similar to those seen in the patient whose case is presented here23 the hematologic findings in thalassemia minor are very similar to those of iron-deficiency anemia3 and folic acid.

Necrotising stomatitis possibly linked to agranulocytosis due to deferiprone has also been described in thalassaemia Tewari et 2009. The genetic defect causes a reduction in the rate of globin chain synthesis which causes the formation of abnormal hemoglobin molecules. However close dental and orthodontic monitoring is crucial.

Dental Manifestations in Thalassemia Patients The orofacial manifestations of thalassemia are due to the bony changes called Cooley facies caused by ineffective erythropoiesis along with the development of bone-expanding erythroid masses Figure 1. PDF ORAL AND MAXILLOFACIAL MANIFESTATIONS IN 50 β THALASSEMIC PATIENTS A CLINICAL STUDY group of websites DISAGREE ORAL AND MAXILLOFACIAL MANIFESTATIONS IN 50 β THALASSEMIC PATIENTS A. Current review of literature and authors recommendations.

1 Severe beta-thalassemia or Cooleys anemia can be separated into. Caution should be exercised in thalassemia patients due to complications related to compromised immunity and. At present the clinical orofacial manifestations caused by the erythroid mass expanding the facial bones - resulting in dental malocclusions and protrusions tend to be less intense as a result of early medical treatment.

National Center for Biotechnology Information. The severity of orofacial manifestations increased with a decline in the systemic health and a deterioration in the blood picture and it was revealed that the rate of prevalence for oral and maxillofacial complications decreases when patients receive blood at younger ages. Their oral manifestations including burning sensation and numbness of oral mucosa dry mouth dysfunction of taste lingual varicosity AG recurrent aphthous ulcerations RAU and oral lichen planus OLP complete blood count and blood chemistry including blood levels of Hb iron vitamin B12 folic acid and homocysteine were inquired examined.

Any dental surgical procedure for such patients should be done. Others develop them during the first two years of life. TT patients had significantly higher frequencies of all oral manifestations than healthy controls p 0001 for all in which burning sensation of oral mucosa 908 lingual varicosity 908.

Overview of Method of Research. A case of thalassemia minor is presented with emphasis on how the condition may affect the dental management of the patient. The resultant microcytic anemia is the characteristic presenting symptom of the thalassemias.

Occlusal abnormalities and bimaxillary protrusions are frequent in patients with thalassemia. This topic review discusses the clinical manifestations and diagnosis of alpha and beta thalassemia the two most common forms. Oral manifestations and complications Oral Surg Oral Med Oral Pathol.

Its causes abnormalitiesin in various human organ including oral and maxillofacial regions. Clinical and orofacial manifestations medical and dental treatment. Dental and jaw pain pallor oral mucosa oral ulceration and burning tongue may also be present secondary to chronic anaemia.

Thalassemia signs and symptoms can include. The main oral manifestations of thalassemia are Class II malocclusion maxillary protrusion high caries index severe gingivitis. An oral examination was conducted to determine dmftDMFT indices Simplified Oral Hygiene Index occlusal anomalies dentofacial.

The main oral manifestations of thalassemia are Class II malocclusion maxillary protrusion high caries index severe gingivitis. The most common are the paleness of the oral mucosa like in every anaemia delayed tooth eruption papillary atrophy of the tongue mandibular osteomyelitis nerve damage to the inferior alveolar. The teeth can be significantly affected in patients with thalassemia but proper transfusion therapy can prevent many of the changes.

Oral manifestations and blood profile in patients with thalassemia trait Article Full-text available Oct 2013 J FORMOS MED ASSOC Yi-Ping Wang Julia Y F Chang Yang-Che Wu Andy Sun View Show abstract. In addition to regular annual dental care thalassemia patients should be evaluated by a dentist to determine if bony changes requiring orthodontic treatments have developed.

Pdf The Thalassemias Oral Manifestations And Complications Semantic Scholar